Projects

A Basic epigenetic mechanisms relevant to physiology and disease

The basic composition of mammalian heterochromatin

Thomas Jenuwein

The interplay between lysine acetyltransferase MOF and ubiquitin ligase MSL2 in development and disease

Asifa Akhtar

Chemical Epigenetics – Inhibitors of histone methyltransferases

Manfred Jung

Epigenetic regulation of TFIID recruitment and activity

Marc Timmers

Regulation of chromatin accessibility by Tbx factors guiding embryonic cell lineage specification

Sebastian Arnold

B In vivo validation of epigenetic control in cellular assays and model organisms

Characterisation of the lysine methyltransferases KMT9 and KMT10

Roland Schüle

Epigenetic effects of NFE2 and JAK2V617F mutations in MPN

Heike Pahl

Epigenetic mechanisms in cardiac failure and recovery

Lutz Hein

Establishment of chromatin states in the early embryo

Nicola Iovino

Epigenetic targeting of dormant leukemic stem cells

Nina Cabezas-Wallscheid

C Translation of epigenetic principles to clinical applications

Lysine-specific demethylases as modulators of CNS glia cell function and neurodegeneration

Marco Prinz

Epigenetic agent treatment through reactivation of repressed, haploinsufficient tumour suppressor genes in high-risk AML

Michael Lübbert

Targeting disease-causing cells by DNA hypomethylation in juvenile myelomonocytic leukaemia

Christian Flotho

Epigenome-wide Association Studies of Kidney Function and Chronic Kidney Disease

Anna Köttgen

Z Central Projects

Deep-Sequencing/Bioinformatics

Thomas Manke
Rolf Backofen

Epigenetic drug design: hit identification, lead optimisation, and target validation

Oliver Einsle
Bernhard Breit
Stefan Günther